Vol.21 No.3

Review Article

The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants


Eitan Israeli1 , Asher Pardo2

  • The Chaim Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621 Tel-Hashomer, Israel
  • Tel-Aviv University and the Institute for Occupational Safety and Hygiene, Tel Aviv, Israel

21 September 2010


25 October 2010

Published online:

29 December 2010

Full Text

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Sick building syndrome (SBS) is a term coined for a set of clinically recognizable symptoms and ailments without a clear cause reported by occupants of a building. In the 1990s the term “functional somatic syndromes” was applied to several syndromes, including SBS, multiple chemical sensitivity, repetition stress injury, the side effects of silicone breast implants, the Gulf War syndrome (GWS), chronic fatigue syndrome, the irritable bowel syndrome, and fibromyalgia. Recently, Shoenfeld and Agmon-Levin suggested that four conditions?siliconosis, macrophagic myofascitis, the GWS, and post-vaccination phenomena?which share clinical and pathogenic resemblances, may be included under a common syndrome entitled the “autoimmune (auto-inflammatory) syndrome induced by adjuvants”. Comparison of the clinical manifestations, symptoms, and signs of the four conditions described by Shoenfeld and Agmon-Levin with those described for SBS shows that nine out of ten main symptoms are present in all 5 conditions. Shoenfeld and Agmon-Levin further propose several major and minor criteria, which, although requiring further validation, may aid in the diagnosis of this newly defined syndrome. We propose here that SBS may also be included as a part of “Shoenfeld’s syndrome”.

Key words

Sick building syndrome - ASIA - Adjuvants - Autoimmune - Vaccination